Developmental Trajectory of SST Interneurons
Mapping how somatostatin interneurons develop their function over time
This study maps how a key class of inhibitory neurons, somatostatin-expressing interneurons, develops their function over time. We found that these neurons undergo specific changes in their visual response properties during development, with implications for understanding both normal brain maturation and neurodevelopmental disorders.
Nature Communications (2025)
Key Findings:
- SST interneurons display a slower trajectory in developing visual responsiveness compared to pyramidal neurons
- SST interneurons may serve to fine-tune and regulate visual processing as circuits mature
- Important implications for understanding neurodevelopmental disorders